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Topical treatment is enough for comedonal adapalene vs tretinoin acne. In case of more severe acne, topical treatment can be combined with systemic treatment Cunliffe and Simpson 1998 Topical treatment of acne vulgaris has changed over the years.Studies in human patients provide clinical evidence that topical adapalene is effective in reducing the inflammatory components of acne i.

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7 Oral isotretinoin roaccutane is currently the gold standard treatment for severe acne.4.

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