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Etoricoxib
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy categoryNot recommended
Routes of administrationOral
ATC codeM01AH05 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability100%
Protein binding92%
MetabolismHepatic, CYP extensively involved (mainly CYP3A4)
Elimination half-life22 hours
ExcretionRenal (70%) and fecal (20%)

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There was an increase in digoxin Cmax approximately 33% This increase is not generally important for most patients. However, patients at high risk of digoxin toxicity should be monitored for this when etoricoxib and digoxin are administered concomitantly. potential cancer risk for <I>Protopic</I> tacrolimus and <I ... Any patients with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormal liver function test has occurred, should be monitored.

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And 4 — abana skin perfector. Etoricoxib is excreted in the etoricoxib 120 mg tablet of lactating rats at concentrations approximately two-fold those in plasma.Based on analyses of long-term placebo and active controlled clinical trials, selective COX-2 inhibitors have been associated with an increased risk of serious thrombotic arterial events, including myocardial etoricoxib 120 mg tablet and stroke.

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If blood pressure rises significantly, alternative treatment should be considered.Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter.

Acetylsalicylic Acid: In a study in healthy etoricoxib 120 dosages, at steady state, etoricoxib 120 mg once daily had no effect on the anti-platelet activity of acetylsalicylic acid 81 mg once daily Etoricoxib can be used concomitantly etoricoxib 120 dosage acetylsalicylic acid at doses used for cardiovascular prophylaxis low-dose acetylsalicylic acid However, concomitant administration of low-dose acetylsalicylic acid with etoricoxib may result in an increased rate of GI ulceration or other complications compared to use of etoricoxib alone.

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